Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 16, 2026JACC Basic to Translational ScienceOpen Access

FOXC1 Controls Smooth Muscle Cell Differentiation and Plasticity in Vascular Disease

View Full Paper
Ask AI
Bookmark
Share

Authors

URUrszula RykaczewskaBSBianca E SuurSNSampath Narayanan

Discussion

Loading...

Member takes

Overview

Randomized trial examines FOXC1's role in smooth muscle cell behavior in vascular disease, suggesting therapeutic targets.

Key Points

  • This research aims to investigate the role of FOXC1 in smooth muscle cell behavior and its implications in vascular diseases.
  • Identified FOXC1 as a transcriptional regulator in vascular injuries and atherosclerotic lesions.
  • Examined the functional role of FOXC1 in smooth muscle cell activation and quiescence.
  • Assessed pathways related to cell adhesion, cell cycle progression, and actin cytoskeleton organization.
  • FOXC1 is causally implicated in vascular injury and the development of atherosclerotic lesions.
  • FOXC1 regulates the balance between smooth muscle cell activation and quiescence by influencing key biological pathways.
  • Targeting FOXC1 may promote lesion stability in vascular diseases.

Cite This Study

Rykaczewska et al. (2026) studied this question.

synapsesocial.com/papers/6a0809bea487c87a6a40b980https://doi.org/10.1016/j.jacbts.2026.101566
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1FOXC1 and Smooth Muscle Cell Plasticity in Human Atherosclerosis2026
  2. 2<scp>FOXC1</scp> : A Key Transcription Factor of <scp>VSMC</scp> ‐Derived Foam Cell Formation in Atherosclerotic Plaque Instability2026
  3. 3FOXC1-FTO axis regulates cardiomyocyte hypertrophy and mitochondrial dysfunction during cardiac hypertrophy in mice.2026
  4. 4The Influence of FOXC1 Gene on Development, Organogenesis, and Functions2024 · 5 citations
  5. 5Abstract 3064: Distinct Regulatory Programs Govern Smooth Muscle Cell Fate In Atherosclerosis2024