• ScvO 2 is positively correlated with SvO₂ but shows limited reliability at the individual level. • Wide LOA indicate ScvO 2 cannot substitute for SvO₂ in surgical patients. • Concordance is higher in non-cardiovascular and off-pump procedures, yet remains limited. The validity of central venous oxygen saturation (ScvO 2 ) as a surrogate for mixed venous oxygen saturation (SvO₂) in surgical patients remains uncertain. We systematically searched PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang, VIP, and the Chinese BioMedical Literature I ² = 70.3%), and LOA (−12.15% to 11.17%) exceeded the predefined ±5% threshold for clinical acceptability, consistent with observations across perioperative phases. The pooled correlation was 0.72 (5 studies, n = 197; 95% CI 0.57–0.82; I ² = 64.3%). Subgroup analyses showed narrower LOA and higher correlation in non-cardiovascular and off-pump procedures. ScvO 2 is positively correlated with SvO₂ in the perioperative period. However, wide individual-level LOA indicate that the two measurements are not interchangeable in surgical patients. LOA are narrower in non-cardiovascular and off-pump procedures but remain outside clinically acceptable limits.
Li et al. (Thu,) studied this question.