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May 16, 2026Journal of the American Heart AssociationOpen Access

Contemporary Overview of Aortic Regurgitation in Young Individuals: Insights From Real‐Life Evidence

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Key result

Proposed algorithm guides severe AR therapy in young adults using multimodality imaging and LV function.

Why the study?

Aortic regurgitation in young adults is often under- or misdiagnosed, and the optimal timing for surgery in asymptomatic chronic disease remains uncertain.

Design

Review

Authors

FSFabiola B. SozziFondazione IRCCS Ca' Granda Ospedale Maggiore PoliclinicoGGGiacomo GamberiniUniversity of MilanJKJin Kyung KimUniversity of California, Irvine

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Implication

May inform individualized AR management decisions in young adults; leaves open prospective validation of the proposed algorithm.

Key Points

  • The aim is to evaluate the prognosis and optimal treatment strategies for aortic regurgitation in young adults.
  • Assessment of aortic regurgitation severity using echocardiography and multimodality imaging.
  • Evaluation of left ventricular function and valve anatomy to guide treatment.
  • Proposal of a treatment algorithm based on disease characteristics.
  • Early intervention improves outcomes in young adults with severe aortic regurgitation.
  • Proposed imaging strategies enhance disease assessment, guiding therapeutic decisions.
  • Aortic valve repair is recommended but often underutilized in this population.

Structured PICO

P
Population
Young adults (aged 18–44 years) with aortic regurgitation
I
Intervention
Multimodality imaging and surgical intervention (aortic valve repair)

This review highlights the importance of multimodality imaging and proposes a treatment algorithm for managing severe aortic regurgitation in young adults, emphasizing aortic valve repair.

Limitations

  • Assessment can be challenging with eccentric jets or complex valve anatomy
  • Current surgical cut-offs remain debated

Cite This Study

Sozzi et al. (2026) conducted a review in Aortic regurgitation. Treatment algorithm and multimodality imaging was evaluated. A proposed treatment algorithm for severe aortic regurgitation in young adults integrates etiology, valve anatomy, and left ventricular function with multimodality imaging to guide therapy.

synapsesocial.com/papers/6a080a11a487c87a6a40bf64https://doi.org/10.1161/jaha.125.048715

Topics

Echocardiography
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