Demonstrates nociceptive sensitivity reduction in Drosophila larvae, indicating the role of Arrow in pain perception.
Normal sensitivity of the Drosophila larval nociceptor requires the activity of the Wg/WNT signaling pathway. When the nociceptor expression of Wg/WNT co-receptor Arrow, Drosophila ortholog of LRP5/6, is impaired by RNA interference, the larva becomes significantly hyposensitive to noxious thermal and mechanical stimulation. The reduced sensitivity was not associated with significant changes in dendritic architecture.
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Flanagan et al. (2026) studied this question.
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