The impact of surgical excision modalities of Merkel cell carcinoma of the head and neck on recurrence, survival, and quality of life: A systematic review

M. Geoffroy; F Alibert; M. Fadel; M. Samimi; S. Boucher

doi:10.1016/j.anorl.2026.01.012

May 1, 2026European Annals of Otorhinolaryngology Head and Neck DiseasesOpen Access

The impact of surgical excision modalities of Merkel cell carcinoma of the head and neck on recurrence, survival, and quality of life: A systematic review

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Key Points

The review assesses the effects of different surgical excision methods on recurrence, survival, and quality of life in head and neck Merkel cell carcinoma.
Systematic search of Medline, Embase, and Web of Science for studies on head and neck Merkel cell carcinoma surgical treatments.
Included 43 studies: 9 cohort studies, 10 case series, and 24 case reports; no randomized clinical trials were found.
Data extraction and risk-of-bias assessment were conducted by two independent reviewers.
No superior technique was identified between Mohs micrographic surgery and wide local excision.
No significant statistical association was found between surgical margin categories or histological status and local control or survival outcomes.
None of the included studies reported data on health-related quality of life in patients with head and neck Merkel cell carcinoma.

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Implication

Systematic review evaluates surgical techniques affecting recurrence and quality of life in head and neck Merkel cell carcinoma, suggesting unclear optimal approach.

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Cite This Study

Geoffroy et al. (2026) studied this question.

synapsesocial.com/papers/6a080a41a487c87a6a40c273 https://doi.org/10.1016/j.anorl.2026.01.012

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The impact of surgical excision modalities of Merkel cell carcinoma of the head and neck on recurrence, survival, and quality of life: A systematic review

Key Points

No abstract yet

Implication

Discussion

Cite This Study

The impact of surgical excision modalities of Merkel cell carcinoma of the head and neck on recurrence, survival, and quality of life: A systematic review

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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