What question did this study set out to answer?

This research aims to identify specific hematoma volume thresholds associated with poor outcomes based on location within the brain during acute intracerebral hemorrhage.

May 16, 2026Journal of the American Heart AssociationOpen Access

Location‐Specific Hematoma Volume Tolerance for Spontaneous Intracerebral Hemorrhage: A Pooled Analysis of INTERACT2 and ATACH II

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This research aims to identify specific hematoma volume thresholds associated with poor outcomes based on location within the brain during acute intracerebral hemorrhage.
Pooled analysis of data from ATACH II and INTERACT2 trials with 1691 patients.
Hematoma volumes assessed via planimetric analysis of CT scans stratified by anatomical locations.
Multivariable logistic regression used to calculate odds ratios for outcomes.
Predictive hematoma volume thresholds for poor outcomes identified: 22.24 mL (basal ganglia), 8.13 mL (thalamus), 21.99 mL (lobar).
Odds ratios indicate stronger predictive values: basal ganglia (OR 4.82), thalamus (OR 2.73), lobar (OR 6.31).
Volume thresholds for death prediction were distinct for locations: 19.72 mL (basal ganglia), 10.06 mL (thalamic), 51.94 mL (lobar).

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Implication

Pooled analysis defines hematoma volume thresholds for outcomes in intracerebral hemorrhage, guiding treatment decisions.

Cite This Study

Brissette et al. (2026) studied this question.

synapsesocial.com/papers/6a080a5aa487c87a6a40c577 https://doi.org/10.1161/jaha.125.049096

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Location‐Specific Hematoma Volume Tolerance for Spontaneous Intracerebral Hemorrhage: A Pooled Analysis of INTERACT2 and ATACH II

Key Points

Discussion

Implication

Cite This Study

Location‐Specific Hematoma Volume Tolerance for Spontaneous Intracerebral Hemorrhage: A Pooled Analysis of INTERACT2 and ATACH II

Key Points

Discussion

Implication

Cite This Study

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