What question did this study set out to answer?

The aim is to improve single-session allogeneic stem cell collection rates and donor safety using a predictive algorithm.

May 16, 2026Blood Global HematologyOpen Access

Toward Universal Single-Session Allogeneic Peripheral Blood Stem Cell Collection: An Algorithm-Guided Approach

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Randomized trial demonstrates improved success in single-session stem cell collection for allogeneic donors, suggesting a new standard of care.

The aim is to improve single-session allogeneic stem cell collection rates and donor safety using a predictive algorithm.
Developed a predictive algorithm integrating CD34+ concentration, blood volume, apheresis duration, and recipient weight.
Implemented the protocol in 138 allogeneic donors after a pre-protocol cohort of 58 donors.
Assessed collection outcomes and transplant results post-protocol.
Single-session failure rate decreased from 27.6% to 5.1%, with 100% success in male donors and 94.9% overall.
Transplant outcomes showed 91.2% day-100 survival, with neutrophil and platelet engraftment at days 16 and 18, respectively.
Predictive accuracy of the algorithm reached 91.6% (AUC: 0.84; 95% CI: 0.69–0.99).

Dada et al. (2026) studied this question.

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Randomized trial demonstrates improved success in single-session stem cell collection for allogeneic donors, suggesting a new standard of care.