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January 1, 2026RSC AdvancesOpen Access

Itraconazole as a repurposed anti-cancer agent: focusing on synthesis, mechanisms of action and therapeutic insights

Mahrokh Marzi Abdolmajid Ghasemian Ali Ghanbariasad Ensieh Nournia Elham Zarenezhad

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Key Points

This research aims to explore itraconazole as a repurposed anti-cancer drug, assessing its mechanisms and therapeutic potential.
Conducted a thorough literature review on itraconazole's synthesis and anti-cancer mechanisms.
Analyzed the existing preclinical and clinical data regarding its therapeutic insights.
Itraconazole shows promise in inhibiting tumor growth through multiple mechanisms of action.
Demonstrated effectiveness in various cancer types, warranting further investigation in clinical settings.

Implication

Demonstrates anti-cancer effects of itraconazole, suggesting potential as a therapeutic agent.

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Cite This Study

Marzi et al. (2026) studied this question.

synapsesocial.com/papers/6a080a71a487c87a6a40c717 https://doi.org/10.1039/d5ra09799a

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Repurposing Itraconazole in Combination with Chemotherapy and Immune Checkpoint Inhibitor for CancerReview · 2026 · 2 citations
2Repurposing the Anti-Fungal Drug Itraconazole for the Treatment of Skin Cutaneous Melanoma: An in-Silico Study2025
3Evaluation of Itraconazole as a repurposed small molecule inhibitor of EMT in breast cancer: a molecular docking and dynamics studyOriginal Research · 2026
4A metabolism-specific drug-repurposing screen reveals itraconazole as a potent OXPHOS inhibitor in acute myeloid leukemiaClinical Trial · 2026
5Revitalizing Cancer Treatment: Exploring the Role of Drug Repurposing2024 · 37 citations

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