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May 16, 2026Indian Pediatrics Case ReportsOpen Access

Infant with Cholestasis, Precocious Puberty, and Café-au-lait Macules: A Case of McCune–Albright Syndrome

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Authors

KNK. C. NehaJWJoshua WesleyMKMNirmal Kumar

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Overview

Randomized trial explores an infant with early cholestasis and precocious puberty, indicating unique MAS presentation.

Key Points

  • To discuss the unique early symptoms of McCune–Albright syndrome in a neonatal case.
  • Case report of a 1-month-old female infant with cholestasis and café-au-lait macules.
  • Monitoring of hormonal levels and imaging for diagnosis.
  • Treatment with letrozole and follow-up at 10 months.
  • Vaginal bleeding and breast development in the infant by 5.5 months.
  • Hormonal tests confirmed gonadotropin-independent precocious puberty.
  • Treatment led to normalization of thyroid and estradiol levels, resolution of ovarian cyst, and stable liver function.

Cite This Study

Neha et al. (2026) studied this question.

synapsesocial.com/papers/6a080a9fa487c87a6a40c7edhttps://doi.org/10.4103/ipcares.ipcares_242_25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Peripheral Precocious Puberty Revealing McCune-Albright Syndrome in a Three-Year-Old Girl: A Case Report2026
  2. 2Early Manifestation of McCune-Albright Syndrome in a 32-Month-Old Female: A Rare Case Report2025
  3. 37291 From Vaginal Bleeding to Genetic Complexity: McCune Albright Syndrome in a Toddler; Emphasizing Atypical Manifestations, Diagnostic Challenges, and Comprehensive Management2024
  4. 4McCune–Albright syndrome with multiple hyperfunctional endocrinopathies: diagnosis, treatment, and long-term follow-up: a case report2025
  5. 5Case Report: Severe McCune–Albright syndrome presenting with neonatal Cushing syndrome: navigating through clinical obstacles2023 · 2 citations