What question did this study set out to answer?

This study aims to evaluate the effectiveness of direct bivalirudin infusion in preserving membrane lung function during ECMO support.

Optimizing Artificial Lung Preservation via Direct Infusion of Bivalirudin Into Extracorporeal Membrane Oxygenation Circuits

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This study aims to evaluate the effectiveness of direct bivalirudin infusion in preserving membrane lung function during ECMO support.
Infusion of bivalirudin directly into ECMO circuits via a dedicated pigtail bridge.
Monitoring anticoagulation levels using aPTT every 6 hours, adjusting to 60-80 s target.
Data collected from over 600 ECMO runs utilizing the bivalirudin administration mechanism.
No safety events related to direct bivalirudin infusion reported.
Bivalirudin administration linked to reduced thrombotic events in ECMO circuits.
Significant improvement in membrane lung preservation indicated by enhanced therapeutic efficacy.

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Randomized trial explores bivalirudin infusion for improved anticoagulation in ECMO, suggesting better circuit performance.

Wieruszewski et al. (2026) studied this question.

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