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May 16, 2026Premier journal of science.Open Access

A Comprehensive Review on Fluconazole: Clinical Efficacy, Pharmacokinetics, and Newly Emerging Challenges of Resistance

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Authors

NVNikita Varfa

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Overview

This comprehensive review evaluates fluconazole’s clinical efficacy and resistance mechanisms, suggesting improved treatment strategies.

Key Points

  • This review aims to summarize the clinical efficacy of fluconazole and the emerging challenges of antifungal resistance.
  • Reviewed existing literature on fluconazole regarding its pharmacokinetics and clinical application.
  • Examined mechanisms of resistance in fungal infections, particularly focusing on mutations and transporters.
  • Discussed antifungal stewardship and personalized medicine to enhance treatment outcomes.
  • Fluconazole shows high oral bioavailability (>90%) and effective tissue distribution against fungal infections.
  • Resistance mechanisms include mutations in the ERG11 gene and overexpression of transporters CDR1 and MDR1.
  • Emphasizes the need for antifungal stewardship and novel drug delivery strategies to combat rising resistance.

Cite This Study

Nikita Varfa (2026) studied this question.

synapsesocial.com/papers/6a080ab3a487c87a6a40ca04https://doi.org/10.70389/pjs.100276
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