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May 16, 2026European Journal of NeuroscienceOpen Access

Functional Dissociation of Mismatch Negativity From Late Discriminative Negativity Across the Adult Lifespan

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Authors

RCRicky ChowYork UniversityJBJennifer A. BugosUniversity of South FloridaCAClaude AlainUniversity of Toronto

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Implication

Randomized trial examines mismatch negativity and late discriminative negativity in adults, suggesting differing roles in auditory perception and memory.

Key Points

  • This study investigates how mismatch negativity (MMN) and late discriminative negativity (LDN) are elicited across the adult lifespan and their functional significance.
  • Examined MMN and LDN from 92 adults aged 18–86 years during acoustic changes in pitch contour within five-tone sequences.
  • Tested incidental memory for standard and deviant tone sequences against similar lures and dissimilar foils.
  • Conducted data-driven analyses of the relationship between event-related potentials and age.
  • LDN was reliably detectable from young to older adulthood, remaining stable, while MMN showed age-related declines.
  • MMN amplitude correlated with age and memory performance, whereas LDN amplitude had weak and inconsistent associations with age and hearing.
  • Findings suggest that MMN and LDN have different functions in detecting oddball stimuli, highlighting their distinct roles in auditory perception.

Cite This Study

Chow et al. (2026) studied this question.

synapsesocial.com/papers/6a080ab3a487c87a6a40ca0dhttps://doi.org/10.1111/ejn.70515
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