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May 16, 2026Cardiovascular Research

Plasma-activated electrospun scaffolds for enhanced endothelialization in vascular tissue engineering

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Authors

FHF HinoveanuRGR GhobeiraSAS Aliakbarshirazi

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Overview

Randomized trial demonstrates enhanced endothelial cell growth in electrospun scaffolds, suggesting improved vascular tissue engineering.

Key Points

  • This study aims to improve vascular tissue engineering by enhancing endothelial cell adhesion and proliferation on electrospun scaffolds through plasma treatment.
  • Electrospun polycaprolactone nanofibers were treated with medium-pressure argon plasma.
  • Surface characterization techniques assessed morphology, chemistry, and wettability.
  • Cell adhesion and proliferation assays were conducted on EA.hy926 endothelial cells.
  • Plasma treatment increased surface oxygen content and transformed nanofibers from hydrophobic to strongly hydrophilic.
  • EA.hy926 endothelial cell adhesion improved significantly, leading to enhanced cell spreading and proliferation.
  • Preservation of structural and mechanical integrity of the nanofibers was maintained post-treatment.

Cite This Study

Hinoveanu et al. (2026) studied this question.

synapsesocial.com/papers/6a080acea487c87a6a40cbf6https://doi.org/10.1093/cvr/cvag092.140
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