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May 16, 2026Expert Review of Cardiovascular Therapy

Cardiac digital twins personalize risk prediction and optimize therapy but high costs demand targeted clinical use.

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Why the study?

Precision cardiac electrophysiology seeks tailored healthcare strategies, and digital twins integrating patient-specific data with mechanistic simulations are fundamental to this approach.

Design

Narrative review

Key result

Cardiac digital twins offer personalized models to predict disease risk and optimize therapy, though their substantial costs require identifying specific clinical applications for greatest value.

Authors

MBMelania BuonocuntoAJAlexander JungSMStefan Meier

Discussion

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Overview

May guide ablation planning in persistent AF; leaves open whether AI precision medicine proves more cost-effective.

Key Points

  • This review aims to explore the concept of digital twins in cardiac electrophysiology and the associated clinical challenges.
  • Summarized state-of-the-art advancements in anatomical and functional digital twins.
  • Discussed technical and clinical challenges related to model development and data integration.
  • Highlighted illustrative case studies and potential clinical applications.
  • Digital twins can potentially guide ablation for patients with persistent atrial fibrillation by mapping out optimal treatment strategies.
  • Potential high costs associated with implementing digital twins require careful identification of patient groups that would benefit.
  • AI-based precision medicine may provide a cost-effective alternative, although digital twins offer superior mechanistic insights when needed.

Structured PICO

I
Intervention
Digital twins in cardiac electrophysiology

Cardiac digital twins offer personalized mechanistic insights that could optimize therapy planning, such as guiding ablation in atrial fibrillation, though cost-effectiveness and clinical implementation remain challenging.

Limitations

  • Potentially substantial costs

Cite This Study

Buonocunto et al. (2026) conducted a review in Cardiac arrhythmias. Digital twins was evaluated. Cardiac digital twins offer personalized models to predict disease risk and optimize therapy, though their substantial costs require identifying specific clinical applications for greatest value.

synapsesocial.com/papers/6a080acea487c87a6a40cc5ehttps://doi.org/10.1080/14779072.2026.2674735
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