Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 16, 2026AnemiaOpen Access

Microtubular Disruption Alters Intestinal Permeability in Murine Neonatal Anemic Intestine

View Full Paper
Ask AI
Bookmark
Share

Authors

MBMarie Amalie BalamuruganNebraska Medical CenterBRBalamurugan RamatchandirinNebraska Medical CenterJRJuanitaa George RajNebraska Medical Center

Discussion

Loading...

Member takes

Implication

Randomized trial investigates how microtubule disruption affects intestinal permeability in neonatal mice, suggesting key mechanisms for anemia-induced gut issues.

Key Points

  • This research aims to explore how microtubular disruption affects intestinal barrier integrity in neonatal anemia.
  • C57BL/6 mice underwent timed phlebotomy between postnatal days 2-10 to induce severe anemia (hematocrits 20%-24%).
  • Microtubular assembly evaluated via electron microscopy, qRT-PCR, immunohistochemistry, and immunoblotting on intestinal tissues.
  • Analyzed ultrastructural changes and expression of α-tubulin 4a (tuba4a) in the context of hypoxia-induced microRNA let-7e.
  • Electron microscopy revealed loss of microtubules and disrupted microtubular assembly in the anemic intestine.
  • Decreased expression of tuba4a was observed, correlating with compromised epithelial barrier functions.
  • The disruption was linked to hypoxia-induced destabilization of tuba4a expression, contributing to the 'leaky gut' phenomenon.

Cite This Study

Balamurugan et al. (2026) studied this question.

synapsesocial.com/papers/6a080acea487c87a6a40cd4bhttps://doi.org/10.1155/anem/6607553
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Anemia, Blood Loss, and Blood Transfusions in North American Children in the Intensive Care Unit2008 · 289 citations
  2. 2Microtubule disassembly increases endothelial cell barrier dysfunction: role of MLC phosphorylation2001 · 175 citations
  3. 3Transfusion thresholds for guiding red blood cell transfusion2021 · 323 citations