Demonstrates unprecedented asymmetric synthesis of helical quinones, indicating a new strategy for chiral helicenes.
Chiral helicenes are widely found in materials science, self-assembly, and asymmetric catalysis, yet their asymmetric construction remains highly challenging. Herein, we report an unprecedented asymmetric synthesis of helical quinones via an enantioselective amine-catalyzed [4+2] annulation. This method features a broad substrate scope, excellent functional group tolerance, and moderate to good yields with high enantioselectivities, providing a new strategy for the construction of chiral helicenes.
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Ji et al. (2026) studied this question.
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