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May 16, 2026Cardiovascular Research

Let-7b in macrophages promotes atherosclerosis progression

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Authors

TGT GuduruKTK TaherdangkooNLN Li

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Overview

Randomized trial demonstrates let-7b promotes atherosclerosis progression in mice, indicating a potential therapeutic target.

Key Points

  • To investigate the role of let-7b in macrophages and its effect on atherosclerosis progression.
  • Generated Apoe–/– mice with myeloid-specific knockout of Mirlet7b and controls.
  • Mice were fed a Western-type diet for 12 or 24 weeks and analyzed for macrophage and cholesterol accumulation.
  • Conducted transcript analysis and dual luciferase reporter assays to identify let-7b targets.
  • Reduced let-7b expression in macrophage plaques of M-mTmG/Let7b–/– mice compared to controls after 12 weeks.
  • Significant decrease in aortic mEGFP+ macrophages area in M-mTmG/Let7b–/– compared to M-mTmG/Let7b+/+ after 12 weeks of diet.
  • Identified Mical2 and Sorcs2 as let-7b targets with reduced transcript abundance in Ago2 IP samples from knockout mice.

Cite This Study

Guduru et al. (2026) studied this question.

synapsesocial.com/papers/6a080b38a487c87a6a40d630https://doi.org/10.1093/cvr/cvag092.185
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