What does this research mean for the field?

Reduced or abnormal deep grey matter on neonatal MRI, particularly as measured by the Kidokoro score, is a consistent independent predictor of cognitive, language, and motor neurodevelopmental outcomes at 2 years' corrected age in very preterm infants. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To assess how neonatal brain MRI findings and perinatal factors relate to neurodevelopmental outcomes in very preterm infants at 2 years.

May 16, 2026Early Human DevelopmentOpen Access

Associations of brain MRI and perinatal factors with 2-year neurodevelopment in very preterm infants

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Authors

TVTânia F. VazUniversity of Lisbon NMNuno Canto MoreiraKarolinska University Hospital NMNuno MatelaUniversity of Lisbon

Discussion

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Implication

Retrospective cohort study evaluates links between brain MRI findings and neurodevelopmental outcomes at 2 years in very preterm infants, highlighting important markers.

Key Points

To assess how neonatal brain MRI findings and perinatal factors relate to neurodevelopmental outcomes in very preterm infants at 2 years.
Retrospective cohort of 50 very preterm infants (<32 weeks) who had neonatal brain MRI at term-equivalent age.
MRI included Kidokoro scores, morphometric measurements, and apparent diffusion coefficients.
Bayley Scales of Infant and Toddler Development assessed cognitive, language, and motor outcomes.
The Kidokoro deep grey matter score is consistently linked to cognitive, language, and motor outcomes.
Explanatory models account for 51.5% of cognitive outcome variance, showing substantial predictability.
Deep grey and white matter Kidokoro scores relate significantly to neurodevelopmental impairment.

Cite This Study

Vaz et al. (2026) studied this question.

synapsesocial.com/papers/6a080b38a487c87a6a40d64e https://doi.org/10.1016/j.earlhumdev.2026.106582

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May 16, 2026Early Human DevelopmentOpen Access

Associations of brain MRI and perinatal factors with 2-year neurodevelopment in very preterm infants

View Full Paper

Ask AI

Bookmark

Authors

TVTânia F. VazUniversity of Lisbon NMNuno Canto MoreiraKarolinska University Hospital NMNuno MatelaUniversity of Lisbon

Discussion

Member takes

Implication

Retrospective cohort study evaluates links between brain MRI findings and neurodevelopmental outcomes at 2 years in very preterm infants, highlighting important markers.

Key Points

To assess how neonatal brain MRI findings and perinatal factors relate to neurodevelopmental outcomes in very preterm infants at 2 years.
Retrospective cohort of 50 very preterm infants (<32 weeks) who had neonatal brain MRI at term-equivalent age.
MRI included Kidokoro scores, morphometric measurements, and apparent diffusion coefficients.
Bayley Scales of Infant and Toddler Development assessed cognitive, language, and motor outcomes.
The Kidokoro deep grey matter score is consistently linked to cognitive, language, and motor outcomes.
Explanatory models account for 51.5% of cognitive outcome variance, showing substantial predictability.
Deep grey and white matter Kidokoro scores relate significantly to neurodevelopmental impairment.

Cite This Study

Vaz et al. (2026) studied this question.

synapsesocial.com/papers/6a080b38a487c87a6a40d64e https://doi.org/10.1016/j.earlhumdev.2026.106582

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