What question did this study set out to answer?

Assess the indications, outcomes, and clinical practices of ovarian tissue cryopreservation in prepubertal girls.

May 16, 2026Minerva Obstetrics and Gynecology

Ovarian tissue cryopreservation in prepubertal girls: a systematic review of indications, outcomes, and clinical practice

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Authors

LMLoris MarinUniversity of Padua KOKutluk OKTAYFoundation for Child Development

Discussion

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Implication

Systematic review evaluates outcomes and practices for ovarian tissue cryopreservation in prepubertal girls, suggesting feasibility with oncologic safety.

Key Points

Assess the indications, outcomes, and clinical practices of ovarian tissue cryopreservation in prepubertal girls.
Systematic review conducted following PRISMA 2020 guidelines with a search through PubMed and other databases.
Inclusion of 45 studies comprising case reports, case series, and cohort studies.
Focus on studies detailing ovarian tissue cryopreservation and transplantation in girls aged 12 years or younger.
Endocrine recovery reported in all documented cases of ovarian tissue transplantation.
Few pregnancies recorded, both spontaneous and ART-assisted, with no disease relapses reported.
In-vitro maturation rates of GV oocytes ranged from 15% to 38%, influenced by age, with improved outcomes after gonadotropin priming.

Cite This Study

Marin et al. (2026) studied this question.

synapsesocial.com/papers/6a080b4ea487c87a6a40d732 https://doi.org/10.23736/s2724-606x.26.05865-3

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Implication

Systematic review evaluates outcomes and practices for ovarian tissue cryopreservation in prepubertal girls, suggesting feasibility with oncologic safety.

Ovarian tissue cryopreservation in prepubertal girls: a systematic review of indications, outcomes, and clinical practice

Discussion

Member takes

Implication

Key Points

Cite This Study

Ovarian tissue cryopreservation in prepubertal girls: a systematic review of indications, outcomes, and clinical practice

Discussion

Member takes

Implication

Key Points

Cite This Study

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