July 3, 2023Circulation Genomic and Precision MedicineOpen Access

PRDM16 Deletion Is Associated With Sex-dependent Cardiomyopathy and Cardiac Mortality: A Translational, Multi-Institutional Cohort Study

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Population

A conditional knockout model

Design

Translational, multi-institutional cohort study

Follow-up

7 months

Authors

RKRyan J. KramerYale University AFAmir Nima FatahianUniversity of Utah ACAlice ChanCedars-Sinai Medical Center

Discussion

Member takes

Implication

May support cardiac screening in PRDM16 deletion carriers; leaves open whether sex-specific strategies improve outcomes.

Structured PICO

Population

Conditional knockout model

Intervention

PRDM16 deletion

Outcome

Fibrosis (assessed by histology and qPCR), echocardiography parameters, and cardiac mortality

PRDM16 deletion is associated with sex-dependent cardiomyopathy and cardiac mortality, suggesting individuals with this deletion should be assessed for cardiac disease.

Cite This Study

Kramer et al. (2023) studied this question.

synapsesocial.com/papers/6a080c973d5e33e469107557 https://doi.org/10.1161/circgen.122.003912

Topics

Cardiomyopathy Cardiac amyloidosis

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PRDM16 Deletion Is Associated With Sex-dependent Cardiomyopathy and Cardiac Mortality: A Translational, Multi-Institutional Cohort Study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

PRDM16 Deletion Is Associated With Sex-dependent Cardiomyopathy and Cardiac Mortality: A Translational, Multi-Institutional Cohort Study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider