Key result
Infarcted canine myocardium exhibited reduced space constants (0.281-0.917 mm) in regions of slow conduction compared to normal epicardial preparations (0.712-1.202 mm).
Population
Canine model, n=18 epicardial preparations
Comparison
Measurement of action potential characteristics… vs Normal ventricular epicardial strips
Design
Preclinical
Follow-up
5-8 days post-occlusion
Authors
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Highlights reduced space constant in post-MI slow conduction; hypothesis-generating for reentry mechanisms, pending human studies.
A reduction in the space constant, along with depressed action potential depolarization and increased effective axial resistance, contributes to slow conduction in chronically infarcted canine myocardium.
Spear et al. (1983) studied Chronically infarcted canine myocardium (n=18). Coronary artery occlusion and reperfusion (infarction) vs. Normal epicardial preparations was evaluated on Space constant and conduction velocity. Infarcted canine myocardium exhibited reduced space constants (0.281-0.917 mm) in regions of slow conduction compared to normal epicardial preparations (0.712-1.202 mm).
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