Key result
Frailty linked to ~145% higher odds of depression in older adults with CHD.
Why the study?
Frailty and depression frequently co-occur in older patients with CHD and are associated with adverse outcomes, but the strength and nature of their association have not been systematically quantified.
Is frailty associated with depression in older adults with coronary heart disease?
Meta-Analysis (n=2,628)
Is frailty associated with depression in older adults with coronary heart disease?
Effect estimate: OR 2.45 (95% CI 1.22-4.92)
p-value: p=0.002
Frailty and depression are significantly associated in older adults with coronary heart disease, supporting integrated screening approaches.
May support integrated screening in frail older CHD patients; leaves open causality and prospective validation.
Background: Frailty and depression frequently co-occur in older patients with coronary heart disease (CHD) and are each associated with adverse outcomes. However, the strength and nature of their association in this population have not been systematically quantified. Methods: statistic. Subgroup analyses were planned by region, study design and assessment tool. Results: = 74%). Conclusion: Frailty and depression are significantly associated in older adults with CHD, supporting integrated screening approaches. However, given the predominance of cross-sectional data, high heterogeneity, and limited cohort evidence, prospective studies are needed to establish temporality and better inform causal inference. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251036929, PROSPERO (CRD420Ò51036929).
No takes yet. Share an insight, caveat, or question.
Chen et al. (2026) conducted a meta-analysis in Coronary heart disease (n=2,628). Frailty was evaluated on Depression (OR 2.45, 95% CI 1.22-4.92, p=0.002). Frailty was significantly associated with increased odds of depression in older adults with coronary heart disease (OR 2.45).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: