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BACKGROUND: To summarise the molecular interactions of Poliovirus Receptor (PVR) with its receptors (inhibitory TIGIT/CD96 and activating CD226), to delineate how these interactions drive glioma immune escape, and to evaluate emerging PVR-directed therapeutic strategies. METHODS: Critical synthesis of pre-clinical and clinical data (to 2025) on PVR pathway biology and drug development in glioma. RESULTS: monoclonal antibodies (e.g. anti-TIGIT/CD96), bispecific engagers, and CAR-modified T/NK cells restores anti-tumour immunity in pre-clinical glioma models, with early-phase trials underway. CONCLUSIONS: The PVR-TIGIT/CD96/CD226 axis is a critical immune checkpoint in glioma. Targeted disruption of this pathway offers a promising strategy to overcome resistance and improve clinical outcomes.
Qian et al. (Tue,) studied this question.