Why the study?
To identify clinical, pathologic, or imaging factors predictive of local relapse after preoperative radiotherapy for soft tissue sarcomas.
What clinical, pathologic, or imaging factors are predictive of local relapse after preoperative radiotherapy for soft tissue sarcomas?
Population
257 patients who underwent preoperative RT and surgery for limb or trunk wall STS
Comparison
Patients stratified by tumor grade and multimodal response factors
Design
Retrospective multicenter study
Follow-up
Median 32 months
Authors
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Trunk wall location and high viable cellularity identify higher-risk STS after preoperative RT; hypothesis-generating for risk-stratified trials.
What clinical, pathologic, or imaging factors are predictive of local relapse after preoperative radiotherapy for soft tissue sarcomas?
The combination of cellularity rate with histotype is a major prognostic factor for local relapse in patients with soft tissue sarcomas treated with preoperative radiotherapy.
Cuenin et al. (2024) studied this question.
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