Cardiorespiratory fitness and morbidity and mortality in patients with non-small cell lung cancer: a prospective study with propensity score weighting

Figures

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  Figure 1.. Flowchart from enrollment to analysis. CPET, cardiopulmonary exercise test; NSCLC, non-small cell lung cancer.

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  Figure 2.. Kaplan–Meier survival curves (A–B) and Forest plots (C–D), before and after applying propensity score overlap weighting (N = 895). CRF, cardiorespiratory fitness; HR, hazard ratio; or, odds ratio. The shadow, along with the curves, represents the 95% confidence interval. *after propensity score overlap weighting, a single individual no longer represents a single data entity.

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  Figure 3.. Subgroup analyses on the association between measured CRF and all-cause mortality (A) and perioperative morbidity (B). BMI, body mass index; CRF, cardiorespiratory fitness; HR, hazard ratio; or, odds ratio.

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  Figure 4.. A Suggested algorithm for using CRF in the assessment of perioperative morbidity risk and long-term mortality in operable patients with early-stage NSCLC. CRF, cardiorespiratory fitness; DLCO, diffusing capacity of the lungs for carbon monoxide; ECG, electrocardiograph; FEV1, forced expiratory volume in one second. aRevised cardiac risk index: (1) high-risk surgery (including lobectomy or pneumonectomy), (2) ischaemic heart disease (prior myocardial infarction, angina pectoris), (3) heart failure, (4) insulin-dependent diabetes, (5) previous stroke of transient ischemic attack, and (6) creatinine ≥2 mg·dL−1. bLow risk in green indicates excellent prognosis and a low risk of perioperative complications. Moderate risk in yellow and high risk in red suggest a progressively worse prognosis and higher a risk of perioperative complications. Patients who are classified as moderate- and high-risk warrant strong consideration of more aggressive medical management and surgical options.