Key result
Being overweight and unfit was associated with a significantly higher risk of mortality compared to being normal weight and fit in patients with stable CVD (HR 1.93; 95% CI 1.55-2.41; P<0.0001).
Why the study?
Both cardiorespiratory fitness and obesity are well-established predictors of cardiometabolic risk and mortality, but their joint association with mortality required investigation in stable CVD.
Does cardiorespiratory fitness mitigate the mortality risk associated with adiposity in cardiac outpatients within a secondary prevention program?
Cohort (n=2,860)
Does cardiorespiratory fitness mitigate the mortality risk associated with adiposity in cardiac outpatients within a secondary prevention program?
Hazard Ratio: 1.93 (95% CI 1.55–2.41)
p-value: p=< .0001
Maintaining cardiorespiratory fitness can mitigate the increased risk of all-cause and cardiovascular mortality associated with overweight and obesity in patients with stable CVD.
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CRF-adiposity joint effects on mortality in stable CVD need prospective confirmation; leaves open refined risk stratification in secondary prevention.
Raisi et al. (2025) conducted a cohort in Stable cardiovascular disease (n=2,860). Low cardiorespiratory fitness and high adiposity (overweight/obese) vs. Normal weight and fit was evaluated on All-cause mortality (HR 1.93, 95% CI 1.55-2.41, p=< .0001). Being overweight and unfit was associated with a significantly higher risk of mortality compared to being normal weight and fit in patients with stable CVD (HR 1.93; 95% CI 1.55-2.41; P<0.0001).
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