The combination of obese BMI and highest cardiorespiratory fitness was associated with lower all-cause mortality compared to normal BMI and least fitness (HR 0.36; 95% CI 0.25-0.51).
Cohort (n=13,521)
Are higher body mass index and cardiorespiratory fitness associated with lower all-cause mortality in patients with chronic kidney disease?
In patients with chronic kidney disease, higher cardiorespiratory fitness is strongly associated with lower all-cause mortality independent of BMI, and higher BMI is also associated with better survival, supporting the obesity paradox.
Hazard Ratio: 0.36 (95% CI 0.25–0.51)
Rationale single baseline BMI and fitness measurements; observational design precludes causal inference. Conclusions In this predominantly male Veteran CKD cohort, higher BMI was associated with lower all-cause mortality across all fitness levels. Age-adjusted CRF demonstrated a strong, graded inverse association with mortality independent of BMI. These observational findings support integrating fitness assessment into CKD management.
Balantrapu et al. (Wed,) conducted a cohort in Chronic Kidney Disease (n=13,521). Higher body mass index and cardiorespiratory fitness vs. Normal BMI and least fit was evaluated on All-cause mortality (HR 0.36, 95% CI 0.25-0.51). The combination of obese BMI and highest cardiorespiratory fitness was associated with lower all-cause mortality compared to normal BMI and least fitness (HR 0.36; 95% CI 0.25-0.51).