Tanshinone IIA alleviates cardiac fibrosis and improves ventricular remodeling following myocardial infarction by downregulating miR-205-3p and upregulating Col1a1 and Col3a1.
Does Tanshinone IIA improve ventricular remodeling and alleviate cardiac fibrosis following myocardial infarction?
Tanshinone IIA demonstrates potential in alleviating cardiac fibrosis and improving ventricular remodeling after myocardial infarction via regulation of miR-205-3p.
Absolute Event Rate: 0% vs 0%
OBJECTIVE: L of TSN in cardiac fibroblasts, relative levels of miR-205-3p, Col1a1, and Col3a1 were detected by quantitative real-time polymerase chain reaction (qRT-PCR). RESULTS: 1 on downregulating miR-205-3p and upregulating Col1a1 and Col3a1 in cardiac fibroblasts. CONCLUSIONS: 1, TSN alleviates cardiac fibrosis and improves ventricular remodeling following MI.
Peng et al. (Mon,) reported a other. Tanshinone IIA alleviates cardiac fibrosis and improves ventricular remodeling following myocardial infarction by downregulating miR-205-3p and upregulating Col1a1 and Col3a1.