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March 10, 2020Frontiers in Cardiovascular Medicine150 citationsOpen Access

Therapeutic Targets for the Treatment of Cardiac Fibrosis and Cancer: Focusing on TGF-β Signaling

WPWarisara ParichatikanondTLTheerut LuangmonkongSMSupachoke Mangmool

Key Result

TGF-β inhibitors offer potential antifibrotic and anticancer therapeutic benefits for the treatment of cardiac fibrosis and cancer based on available clinical data.

Structured PICO

I
Intervention
TGF-β signaling inhibitors (including small molecule inhibitors, antibodies, and gene deletion)

Targeting TGF-β signaling pathways represents a promising therapeutic strategy for the treatment of both cardiac fibrosis and cancer.

Abstract

evidence regarding antifibrotic and anticancer actions of TGF-β inhibitors. In addition, we also present available clinical data on therapy based on inhibiting TGF-β signaling for the treatment of cancers and cardiac fibrosis.

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Cite This Study

Parichatikanond et al. (2020) studied this question. TGF-β inhibitors offer potential antifibrotic and anticancer therapeutic benefits for the treatment of cardiac fibrosis and cancer based on available clinical data.

synapsesocial.com/papers/6a0827b7df3db87398107e90https://doi.org/10.3389/fcvm.2020.00034
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