Key result
Reversible perfusion defects on MPI linked to ~25% higher epicardial fat volume.
Why the study?
The study was conducted to compare epicardial fat volume measured by MPI SPECT/CT between patients with normal and abnormal myocardial perfusion in known or suspected CAD.
Is epicardial fat volume increased in patients with reversible perfusion abnormalities compared to those with normal perfusion on MPI SPECT/CT?
Cross-Sectional (n=176)
No
Is epicardial fat volume increased in patients with reversible perfusion abnormalities compared to those with normal perfusion on MPI SPECT/CT?
Absolute Event Rate: 92.94% vs 74.46%
p-value: p=<0.001
Epicardial fat volume was associated with reversible ischemia on MPI; hypothesis-generating for CAD risk stratification.
PURPOSE OF THE STUDY: Our study purpose was to compare the epicardial fat volume (EFV) in myocardial perfusion imaging single photon emission computed tomography/computed tomography (MPI SPECT/CT) with normal and abnormal perfusion in patients with known or suspected coronary artery disease (CAD). MATERIALS AND METHODS: one hundred and seventy-six patients (88 records with normal and 88 with reversible perfusion defects) underwent physical or adenosine stress with Tc-99m MIBI followed by SPECT and low-dose CT for attenuation correction. Rest MPI was done in patients showing perfusion defects on stress imaging. Software-based quantification of EFV was done by manually delineating pericardial contours with epicardial fat threshold set between -30 HU and -190 HU. RESULTS: < 0.001). CONCLUSION: < 0.001) suggesting potential role of cardiac SPECT/CT to evaluate EFV for risk stratification of suspected CAD.
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Kilambi et al. (2021) conducted a cross-sectional in Suspected or known coronary artery disease (n=176). Reversible perfusion defects (Ischemia) vs. Normal perfusion was evaluated on Epicardial fat volume (EFV) (p=<0.001). Patients with reversible perfusion defects on myocardial perfusion imaging had a significantly increased median epicardial fat volume of 92.94 ml compared to 74.46 ml in patients with normal perfusion.
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