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August 1, 1986Journal of Medicinal Chemistry

Plant antitumor agents. 22. Isolation of 11-hydroxycamptothecin from Camptotheca acuminata decne: total synthesis and biological activity

Monroe E. Wall Mansukh C. Wani S. M. NATSCHKE Allan W. Nicholas

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Abstract

The antitumor alkaloid 11-hydroxy-(20S)-camptothecin was isolated from the woody tissue of Camptotheca acuminata. Structural proof derived from comparison with racemic 4 prepared by total synthesis. Antitumor activity of racemic 4 in L1210 leukemia in mice was considerably greater than that of natural (20S)-camptothecin and its sodium salt. There was also no toxic effect observed even at relatively high doses.

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Wall et al. (1986) studied this question.

synapsesocial.com/papers/6a082ba61e0fcf4a43e8ade7 https://doi.org/10.1021/jm00158a044

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