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November 10, 1984BMJOpen Access

Distribution of adipose tissue and risk of cardiovascular disease and death: a 12 year follow up of participants in the population study of women in Gothenburg, Sweden.

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Key result

The ratio of waist to hip circumference showed a significant positive association with the 12-year incidence of myocardial infarction, angina pectoris, stroke, and death.

Why the study?

Does the ratio of waist to hip circumference predict the incidence of myocardial infarction, angina pectoris, stroke, and death in women?

Population

1462 women aged 38-60 from Gothenburg, Sweden

Design

Cohort

Follow-up

12 years

Authors

LLLeif LapidusRiga East University HospitalCBCalle BengtssonMercer (Czechia)BLB. LarssonUppsala University

Discussion

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Implication

Waist-to-hip ratio may flag higher cardiovascular risk in women; leaves open its added value beyond standard predictors.

Key Points

  • To investigate the relationship between adipose tissue distribution and cardiovascular disease risk over 12 years.
  • Longitudinal population study of 1462 women aged 38-60 conducted in Gothenburg, Sweden from 1968-9.
  • Analyzed the association between waist to hip circumference ratio and cardiovascular events using univariate and multivariate analyses.
  • Controlled for variables like age, body mass index, smoking, cholesterol levels, triglycerides, and systolic blood pressure.
  • Waist to hip ratio significantly associated with myocardial infarction, angina pectoris, stroke, and death (p<0.05).
  • Multivariate analysis confirmed that waist to hip ratio independently predicted myocardial infarction risk.
  • Stronger correlation found for waist to hip ratio compared to other anthropometric measures.

Study Design

Type

Cohort (n=1,462)

Multicenter

No

Structured PICO

Does the ratio of waist to hip circumference predict the incidence of myocardial infarction, angina pectoris, stroke, and death in women?

P
Population
1462 women aged 38-60 from Gothenburg, Sweden
I
Intervention
Waist to hip circumference ratio (exposure)
O
Outcome
12 year incidence of myocardial infarction, angina pectoris, stroke, and deathhard clinical

Waist-to-hip ratio is a strong, independent anthropometric predictor of cardiovascular events and mortality in women.

Cite This Study

Lapidus et al. (1984) conducted a cohort in Cardiovascular disease (n=1,462). Ratio of waist to hip circumference was evaluated on Incidence of myocardial infarction, angina pectoris, stroke, and death. The ratio of waist to hip circumference showed a significant positive association with the 12-year incidence of myocardial infarction, angina pectoris, stroke, and death.

synapsesocial.com/papers/6a082bfbad370a6b44ddfa1ahttps://doi.org/10.1136/bmj.289.6454.1257

Topics

Women and heart disease
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study.1983 · 4,274 citations
  2. 2Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913.1984 · 1,944 citations
  3. 3HIGH BLOOD PRESSURE IN WOMEN1982 · 62 citations
  4. 4The Population Study of Women in Göteborg 1974–1975 —the Second Phase of a Longitudinal Study: General Design, Purpose and Sampling Results1978 · 106 citations
  5. 5A STROKE REGISTER IN GÖTEBORG, SWEDEN1972 · 54 citations