Key result
Lumped parameter circuit model successfully simulates normal cardiac hemodynamics with good biological agreement.
An analog circuit analogy model successfully simulates normal cardiac operation and hemodynamics, showing good agreement with biological data.
Provides a platform for in silico hemodynamic testing; extends computational research while leaving clinical translation open.
Cardiovascular disease is one of major diseases that contribute to mortalities and morbidities in industrialized countries. Seeking an in-depth understanding of what happens in the human body involving cardiovascular disease leads to investigation of the system using cardiovascular model. The objective of this work is to develop and analyze a model of the human cardiovascular system capable of simulating normal cardiac operation based on circuit analogy. To simulate the entire cardiovascular system, the models are divided to into three sub-systems: pulmonary circuit, cardiac circuit (consisting of left and right heart circuits) and systemic circuit. Modeling hemodynamics of blood flow circulation uses an electric circuit analogy called the lumped parameter method. Parameters of the model have been extracted from existing literature. Based on a previous model, the present work analyzes pumping characteristics of the cardiovascular system with 1 and 3 AC sources. It also investigates contraction of arterial characteristics when added at the right and left atriums. Simulation results are found to be in good agreement with biological data.
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Ismail et al. (2018) studied Cardiovascular system modeling. Analog circuit analogy modeling (lumped parameter method) was evaluated on Simulation of normal cardiac operation and hemodynamics. A lumped parameter circuit model of the human cardiovascular system successfully simulated normal cardiac operation and hemodynamics, showing good agreement with biological data.