Why the study?
Does hexarelin improve pulsatile GH secretion and metabolic hormones in streptozotocin-induced diabetic rats?
Population
Streptozotocin (STZ, 65 mg/kg)-induced diabetic rats (four-week-long) and vehicle control rats
Comparison
Daily hexarelin treatment for two weeks vs STZ-rats without hexarelin treatment and vehicle…
Design
Preclinical
Follow-up
two weeks
Authors
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May normalize GH pulsatility and FFAs in diabetic rats without IGF-1 recovery; leaves open whether GHSR agonists merit human translation studies.
Does hexarelin improve pulsatile GH secretion and metabolic hormones in streptozotocin-induced diabetic rats?
In a diabetic rat model, hexarelin normalized impaired pulsatile GH secretion and fasting FFA levels, though it did not recover IGF-1 levels.
Zhang et al. (2018) studied this question.
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