Why the study?
Does adeno-associated virus-based MCU transgene expression improve mitochondrial calcium handling and cardiac function in diabetic mouse hearts?
Does adeno-associated virus-based MCU transgene expression improve mitochondrial calcium handling and cardiac function in diabetic mouse hearts?
Restoring mitochondrial calcium uniporter expression via AAV in diabetic mouse hearts improves mitochondrial calcium handling and cardiac function.
Does not support clinical use of MCU gene therapy; leaves open translation of mitochondrial calcium restoration to human diabetic cardiomyopathy.
handling and its negative consequences can be ameliorated in diabetes by restoring MCU levels via adeno-associated virus-based MCU transgene expression.
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Suárez et al. (2018) studied this question.
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