Outcome of Debridement, Antibiotics, and Implant Retention for Staphylococcal Hip and Knee Prosthetic Joint Infections, Focused on Rifampicin Use: A Systematic Review and Meta-Analysis

Henk Scheper; Laura M. Gerritsen; Bart G. Pijls; Suzanne Van Asten; Leo G. Visser; Mark de Boer

doi:10.1093/ofid/ofab298

July 1, 2021Open Forum Infectious DiseasesOpen Access

Outcome of Debridement, Antibiotics, and Implant Retention for Staphylococcal Hip and Knee Prosthetic Joint Infections, Focused on Rifampicin Use: A Systematic Review and Meta-Analysis

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Key Points

This review aims to evaluate the effectiveness of rifampicin in treating staphylococcal prosthetic joint infections.
Conducted a systematic review and meta-analysis of existing studies on rifampicin use in PJI.
Focused on success rates of treating coagulase-negative staphylococci (CNS) and methicillin-resistant Staphylococcus aureus (MRSA).
Analyzed outcomes based on treatment responses in knee and hip prosthetic joint infections.
Success rates for coagulase-negative staphylococci in knee infections were 83% and hip infections were 73%.
Success rates for MRSA (58%) were similar to MSSA (60%).
Rifampicin appeared to prevent only a small fraction of treatment failures based on meta-analysis data.

Implication

Systematic review finds rifampicin only slightly reduces treatment failures in staphylococcal joint infections.

Abstract

knee PJI, 83% for coagulase-negative staphylococci (CNS) hip PJI, and 73% for CNS knee PJI. Success rates for MRSA PJI (58%) were similar to MSSA PJI (60%). The meta-analysis indicates that rifampicin may only prevent a small fraction of all treatment failures.

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Cite This Study

Scheper et al. (2021) studied this question.

synapsesocial.com/papers/6a083385afa0a1b8dbddefaa https://doi.org/10.1093/ofid/ofab298

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Outcome of Debridement, Antibiotics, and Implant Retention for Staphylococcal Hip and Knee Prosthetic Joint Infections, Focused on Rifampicin Use: A Systematic Review and Meta-Analysis

Key Points

Implication

Abstract

Discussion

Cite This Study

Outcome of Debridement, Antibiotics, and Implant Retention for Staphylococcal Hip and Knee Prosthetic Joint Infections, Focused on Rifampicin Use: A Systematic Review and Meta-Analysis

Key Points

Implication

Abstract

Discussion

Cite This Study

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