Key result
Rivaroxaban and apixaban show similar efficacy and safety for cancer-associated VTE in lower-bleeding-risk patients.
Why the study?
Does rivaroxaban compared to apixaban reduce the composite of recurrent VTE or bleeding-related hospitalization in adult patients with cancer-associated VTE at lower risk of bleeding?
Does rivaroxaban compared to apixaban reduce the composite of recurrent VTE or bleeding-related hospitalization in adult patients with cancer-associated VTE at lower risk of bleeding?
In a real-world cohort of patients with cancer-associated VTE at lower bleeding risk, rivaroxaban and apixaban demonstrated similar effectiveness and safety at 3 and 6 months.
Supports either agent in lower-bleeding-risk cancer VTE; extends real-world data but leaves open need for RCTs.
Rivaroxaban and apixaban have similar effectiveness and safety for treatment of cancer-associated VTE through 6 months.Clinicians should therefore consider patient preference and adherence when choosing the optimal anticoagulant.
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Caroti et al. (2023) studied this question. Rivaroxaban and apixaban demonstrated similar effectiveness and safety for the treatment of cancer-associated venous thromboembolism through 6 months in patients at lower risk of bleeding.
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