Why the study?
Does concurrent use of NSAIDs and oral anticoagulants increase the risk of hemorrhagic peptic ulcer disease in elderly persons?
Population
103,954 Tennessee Medicaid enrollees aged 65 years or older
Comparison
Concurrent use of oral anticoagulants and… vs Nonusers of either drug
Design
Cohort
Follow-up
209,066 person-years total (1984 through 1986)
Key result
Concurrent use of oral anticoagulants and NSAIDs in elderly persons increased the risk of hemorrhagic peptic ulcer disease nearly 13-fold compared to nonusers (RR 12.7; 95% CI 6.3 to 25.7).
Authors
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Associated with high hemorrhagic ulcer risk in elderly anticoagulant users; leaves open need for randomized confirmation and mitigation strategies.
Cohort (n=103,954)
Does concurrent use of NSAIDs and oral anticoagulants increase the risk of hemorrhagic peptic ulcer disease in elderly persons?
Effect estimate: RR 12.7 (95% CI 6.3 to 25.7)
Concurrent use of oral anticoagulants and NSAIDs in elderly patients is associated with a nearly 13-fold increased risk of hemorrhagic peptic ulcer disease, highlighting the need for extreme caution when co-prescribing these medications.
Ronald I. Shorr (1993) conducted a cohort in Hemorrhagic peptic ulcer disease (n=103,954). Concurrent use of oral anticoagulants and NSAIDs vs. Nonusers of either drug was evaluated on Hemorrhagic peptic ulcer disease (RR 12.7, 95% CI 6.3 to 25.7). Concurrent use of oral anticoagulants and NSAIDs in elderly persons increased the risk of hemorrhagic peptic ulcer disease nearly 13-fold compared to nonusers (RR 12.7; 95% CI 6.3 to 25.7).