Observational study reveals increased peptic ulcer disease risk from nonaspirin NSAID use in elderly persons, indicating dose-dependent gastrointestinal toxicity.
These data support other findings indicating that a clinically significant risk for serious ulcer disease is associated with the use of nonaspirin nonsteroidal anti-inflammatory drugs. The data show that this risk increases with dose and recency of use and that use of these drugs may be responsible for a large proportion of peptic ulcer disease among elderly persons.
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Griffin et al. (1991) studied this question.
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