What question did this study set out to answer?

To evaluate the relationship between non-steroidal anti-inflammatory drug (NSAID) use and peptic ulcer perforation across different age demographics.

April 1, 1985GutOpen Access

Non-steroidal anti-inflammatory drugs and peptic ulcer perforation.

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Authors

DCDean CollierUniversity of Nebraska at Omaha JPJ A PainRoyal Surrey County Hospital

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Implication

Retrospective case-control study reveals increased peptic ulcer perforation from non-steroidal anti-inflammatory drugs in elderly patients, highlighting heightened vulnerability in older adults.

Key Points

To evaluate the relationship between non-steroidal anti-inflammatory drug (NSAID) use and peptic ulcer perforation across different age demographics.
Retrospective case-control study comparing NSAID ingestion between 269 patients with perforated peptic ulceration and 269 age- and sex-matched controls admitted between 1973 and 1982.
Analyzed regional correlation between annual NSAID prescription numbers and hospital admissions for perforated peptic ulcers stratified by age (<65 vs. >65 years).
A highly significant increase in NSAID ingestion was observed in patients with perforated peptic ulcers aged over 65 years compared to controls (p < 0.001), with no significant difference seen in those under 65 years.
Annual regional NSAID prescription volume correlated significantly with perforated peptic ulcer admissions among individuals aged over 65 years (p < 0.0001), but showed no correlation in individuals under 65 years.

Cite This Study

Collier et al. (1985) studied this question.

synapsesocial.com/papers/6a7151fd75498292b70acc17 https://doi.org/10.1136/gut.26.4.359

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Implication

Retrospective case-control study reveals increased peptic ulcer perforation from non-steroidal anti-inflammatory drugs in elderly patients, highlighting heightened vulnerability in older adults.

Non-steroidal anti-inflammatory drugs and peptic ulcer perforation.

Discussion

Member takes

Implication

Key Points

Cite This Study

Non-steroidal anti-inflammatory drugs and peptic ulcer perforation.

Discussion

Member takes

Implication

Key Points

Cite This Study

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