Key result
The risk of gastrointestinal hospitalization attributable to aspirin varied by NSAID, ranging from none with naproxen to 61% with celecoxib, and was higher with COX-2 inhibitors.
Why the study?
Does the addition of low-dose aspirin to different NSAIDs increase the risk of gastrointestinal hospitalizations in patients 50 years or older?
Cohort
Does the addition of low-dose aspirin to different NSAIDs increase the risk of gastrointestinal hospitalizations in patients 50 years or older?
Hazard Ratio: 3.2 (95% CI 2.8–3.7)
The addition of low-dose aspirin to NSAIDs increases the risk of gastrointestinal hospitalizations, with the attributable risk being higher when combined with COX-2 inhibitors than with non-selective NSAIDs.
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May warrant caution combining aspirin with COX-2 inhibitors in older adults; leaves open NSAID-specific risk differences for randomized confirmation.
Rahme et al. (2007) conducted a cohort in Patients using NSAIDs or acetaminophen. Low-dose aspirin combined with NSAIDs vs. Acetaminophen without aspirin was evaluated on Gastrointestinal hospitalizations (HR 3.2, 95% CI 2.8-3.7). The risk of gastrointestinal hospitalization attributable to aspirin varied by NSAID, ranging from none with naproxen to 61% with celecoxib, and was higher with COX-2 inhibitors.
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