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January 1, 1989Arteriosclerosis An Official Journal of the American Heart Association IncOpen Access

Molecular modeling of protein-glycosaminoglycan interactions.

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Authors

ACA D CardinUniversidade Estadual de MaringáHWHerschel J. R. WeintraubPurdue University West Lafayette

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Implication

Randomized trial identifies potential heparin-binding regions in proteins, highlighting implications for atherosclerosis.

Key Points

  • The aim is to identify potential heparin-binding sites on proteins using sequence analysis.
  • Identified 49 regions in 21 proteins as potential heparin-binding sites.
  • Utilized consensus sequences and predictive algorithms to determine binding domains.
  • Modeled the heparin-binding domain of vitronectin using circular dichroism studies.
  • Identified consensus sequences for glycosaminoglycan recognition: [-X-B-B-X-B-X-] and [-X-B-B-B-X-X-B-X-].
  • Modeled heparin-binding pocket in vitronectin showed complementary structure to heparin octasaccharide.
  • Discussion includes the relevance of protein-glycosaminoglycan interactions to atherosclerosis.

Cite This Study

Cardin et al. (1989) studied this question.

synapsesocial.com/papers/6a0838d0df3db87398108392https://doi.org/10.1161/01.atv.9.1.21
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