Key result
Random 2-hour CrCl correlates with and can replace 24-hour clearance in most ICU patients.
Why the study?
Does 2-hour creatinine clearance correlate with and replace 24-hour creatinine clearance in ICU patients?
Does 2-hour creatinine clearance correlate with and replace 24-hour creatinine clearance in ICU patients?
In ICU patients, 24-hour creatinine clearance can generally be replaced by a random 2-hour creatinine clearance, factoring in body temperature, age, and serum creatinine D-value.
May support abbreviated creatinine clearance monitoring in ICU; leaves open prospective validation before practice change.
There is significant correlation and consistency between 2hCcr and 24hCcr in ICU patients.And in most of the cases, the 24hCcr can be replaced by random 2hCcr, but the affecting factors of body temperature, age and the D-value of serum creatinine should be taken into account.
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Jia et al. (2018) studied this question. A random 2-hour creatinine clearance significantly correlates with and can replace 24-hour clearance in most ICU patients, accounting for body temperature, age, and serum creatinine changes.
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