What question did this study set out to answer?

To develop a formula predicting creatinine clearance from serum creatinine levels in adult males based on age and body weight.

January 1, 1976Nephron

Prediction of Creatinine Clearance from Serum Creatinine

View Full Paper

Ask AI

Bookmark

Key result

A new formula predicting creatinine clearance from serum creatinine in adult males shows a correlation coefficient of 0.83 with measured Ccr values.

Why the study?

Does a new formula incorporating serum creatinine, age, and body weight accurately predict creatinine clearance in adult patients?

Population

Adult patients aged 18-92

Comparison

A newly developed formula to predict creatinine… vs Four other prediction methods and measured…

Design

Cohort

Authors

DCDonald W. CockcroftUniversity of Saskatchewan HGHenry GaultSt. John's Hospital

Discussion

Member takes

Implication

May support creatinine clearance estimation via serum creatinine, age, and weight in adult males; leaves open external validation.

Key Points

To develop a formula predicting creatinine clearance from serum creatinine levels in adult males based on age and body weight.
Analyzed data from 249 patients aged 18-92 to establish relationships between age and creatinine excretion.
Developed a predictive formula based on serum creatinine levels.
Compared predicted creatinine clearance values using the formula and four other methods with measured values from 236 patients.
The formula achieved a correlation coefficient of 0.83 with mean measured creatinine clearance.
Predicted values were consistent with measured clearances, showing no significant difference on average.
Including age and body weight factors improved prediction accuracy.

Structured PICO

Does a new formula incorporating serum creatinine, age, and body weight accurately predict creatinine clearance in adult patients?

Population

Adult patients aged 18-92

Intervention

A newly developed formula to predict creatinine clearance (Ccr) from serum creatinine (Scr), age, and body weight

Comparator

Four other prediction methods and measured 24-hour creatinine clearance

Outcome

Correlation and difference between predicted and measured creatinine clearancesurrogate

A newly developed formula incorporating serum creatinine, age, and body weight provides a reasonable prediction of creatinine clearance in adults.

Cite This Study

Cockcroft et al. (1976) studied this question. A new formula predicting creatinine clearance from serum creatinine in adult males shows a correlation coefficient of 0.83 with measured Ccr values.

synapsesocial.com/papers/696bdcb250a360e9ca11988d https://doi.org/10.1159/000180580

Topics

Coronary artery disease

View Full Paper

Ask AI

Bookmark

Prediction of Creatinine Clearance from Serum Creatinine

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Prediction of Creatinine Clearance from Serum Creatinine

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider