Why the study?
Does predicted creatinine clearance provide a reasonable approximation of renal clearance for dosage adjustments in geriatric patients compared to measured 24-hour creatinine clearance or serum creatinine alone?
Population
Geriatric patients requiring renally eliminated drugs
Comparison
Prediction of creatinine clearance based on… vs Measured 24-hour creatinine clearance or serum…
Design
Review
Authors
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Predicted CLcr may guide geriatric dosing without urine collection; leaves open prospective validation versus measured clearance in acute illness or wasting.
Does predicted creatinine clearance provide a reasonable approximation of renal clearance for dosage adjustments in geriatric patients compared to measured 24-hour creatinine clearance or serum creatinine alone?
Predicted creatinine clearance using age and body weight is a practical alternative to 24-hour urine collection for drug dosing in the elderly, except in specific conditions like acute renal failure or muscle wasting.
Sanaka et al. (1996) studied this question.
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