Why the study?
Does rounding serum creatinine to 1.0 mg/dL affect the accuracy of creatinine clearance estimates and aminoglycoside dosing in elderly patients with low serum creatinine?
Population
Elderly hospitalized patients with stable renal function and low serum creatinine concentrations
Comparison
Calculating creatinine clearance by rounding the… vs Calculating CLcr using the actual SCr…
Design
Cross-sectional
Authors
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Caution against rounding SCr to 1.0 mg/dL for aminoglycoside dosing in elderly with low SCr; leaves open prospective validation of dosing accuracy.
Does rounding serum creatinine to 1.0 mg/dL affect the accuracy of creatinine clearance estimates and aminoglycoside dosing in elderly patients with low serum creatinine?
In elderly patients with low serum creatinine, rounding SCr to 1.0 mg/dL significantly underestimates creatinine clearance and aminoglycoside dosing requirements.
Smythe et al. (1994) studied this question.
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