Key result
High levels of fibrinogen, viscosity, and white blood cell count were associated with increased odds of ischemic heart disease (OR 4.1, 4.5, and 3.2, respectively, for top vs bottom 20%).
Why the study?
Are elevated levels of fibrinogen, viscosity, and white blood cell count associated with an increased risk of ischemic heart disease in middle-aged men?
Population
4,860 middle-aged men from the general population
Comparison
Top 20% of the distribution for fibrinogen… vs Bottom 20% of the distribution for fibrinogen…
Design
Cohort
Follow-up
5.1 years in Caerphilly and 3.2 years in Speedwell
Authors
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Elevated fibrinogen, viscosity, and WBC count may refine IHD risk stratification in middle-aged men; leaves open incremental value beyond conventional factors.
Cohort (n=4,860)
Yes
Are elevated levels of fibrinogen, viscosity, and white blood cell count associated with an increased risk of ischemic heart disease in middle-aged men?
Effect estimate: OR 4.1 (fibrinogen), OR 4.5 (viscosity), OR 3.2 (WBC) (95% CI 2.6-6.5 (fibrinogen), 2.8-7.4 (viscosity), 2.0-4.9 (WBC))
Fibrinogen, viscosity, and white blood cell count are independent risk factors for ischemic heart disease, with predictive value comparable to conventional risk factors like cholesterol and blood pressure.
Yarnell et al. (1991) conducted a cohort in Ischemic heart disease (n=4,860). Top 20% of fibrinogen, viscosity, and white blood cell count vs. Bottom 20% of distribution was evaluated on Incidence of major IHD events (OR 4.1 (fibrinogen), OR 4.5 (viscosity), OR 3.2 (WBC), 95% CI 2.6-6.5 (fibrinogen), 2.8-7.4 (viscosity), 2.0-4.9 (WBC)). High levels of fibrinogen, viscosity, and white blood cell count were associated with increased odds of ischemic heart disease (OR 4.1, 4.5, and 3.2, respectively, for top vs bottom 20%).
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