Key result
VA-ECMO improves fulminant myocarditis survival, especially in younger adults without prior cardiac arrest.
Why the study?
Fulminant myocarditis is a life-threatening disease requiring emergency care, and differences in clinical outcomes and survival predictors with VA-ECMO between adult and pediatric populations needed exploration.
What are the predictors of survival in adult and pediatric patients with fulminant myocarditis treated with VA-ECMO?
Meta-Analysis
What are the predictors of survival in adult and pediatric patients with fulminant myocarditis treated with VA-ECMO?
p-value: p=<0.01
In patients with fulminant myocarditis requiring VA-ECMO, younger age in adults and the absence of prior cardiac arrest are significant predictors of improved survival.
VA-ECMO may improve survival in fulminant myocarditis; supports age and arrest history as prognostic factors but leaves optimal selection open pending RCTs.
Background: Fulminant myocarditis (FM) is a potentially life-threatening disease that requires emergency care. The authors' study aims to explore clinical outcomes and predictors of survival when using veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support for the treatment of FM in adult and pediatric patients to analyze differences between both populations. Methods: PubMed, Scopus, Web of Science, and Cochrane databases were searched for studies reporting the effect of VA-ECMO on patients diagnosed with fulminant myocarditis. Statistical analysis was performed using R version 4.2.2. Results: <0.01). Furthermore, no significant association was detected between sex, VA-ECMO duration, systolic blood pressure, lactate levels, and survival rates among both groups. Conclusion: Using VA-ECMO in patients with fulminant myocarditis can significantly improve survival outcomes, with improved prognosis observed with younger age among adults and absence of prior history of cardiac arrest in both groups.
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Dean et al. (2024) conducted a meta-analysis in Fulminant myocarditis. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) was evaluated on Survival rates (p=<0.01). VA-ECMO support in fulminant myocarditis improves survival, with younger age in adults and absence of prior cardiac arrest predicting better prognosis.
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