Key result
Serum IL-2 concentrations were abnormally increased in patients with idiopathic dilated cardiomyopathy and their relatives with asymptomatic left ventricular enlargement.
Why the study?
Do patients with idiopathic dilated cardiomyopathy and their asymptomatic relatives have abnormal serum cytokine profiles compared to healthy controls and patients with ischaemic heart failure?
Population
80 individuals: 20 patients with idiopathic dilated cardiomyopathy, 20 relatives with asymptomatic left…
Design
Case-control
Authors
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Suggests immune dysregulation in idiopathic DCM families; hypothesis-generating without supporting clinical cytokine testing or therapy changes.
Cross-Sectional (n=80)
Do patients with idiopathic dilated cardiomyopathy and their asymptomatic relatives have abnormal serum cytokine profiles compared to healthy controls and patients with ischaemic heart failure?
Patients with idiopathic dilated cardiomyopathy and their asymptomatic relatives with left ventricular enlargement exhibit abnormal cytokine profiles (increased IL-2 and IL-10), suggesting defective T cell function.
Marriott et al. (1996) conducted a cross-sectional in Idiopathic dilated cardiomyopathy (n=80). Cytokine profile measurement vs. Healthy controls and ischaemic heart failure patients was evaluated on Serum concentrations of IL-2, IL-4, IL-10, and IL-12. Serum IL-2 concentrations were abnormally increased in patients with idiopathic dilated cardiomyopathy and their relatives with asymptomatic left ventricular enlargement.
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