Key result
Hypertension and diabetes were independently associated with a 3.46-fold and 4.45-fold higher risk of chronic kidney disease, which had an overall prevalence of 6.3% among adults in Luxembourg.
Cross-Sectional (n=1,361)
Effect estimate: OR 3.46 (95% CI 1.92-6.24)
p-value: p=<0.001
In a nationwide Luxembourg cohort, the prevalence of CKD was 6.3%, strongly driven by cardiovascular risk factors such as hypertension and diabetes, emphasizing the need for early screening in these high-risk groups.
Hypertension and diabetes were associated with higher CKD odds in Luxembourg adults; extends European prevalence data but leaves screening impact open.
BACKGROUND: Evidence on stages of renal impairment and related risk factors in Luxembourg is lacking. This study aimed to assess the prevalence of chronic kidney disease (CKD) and identify potential correlates among the general population, using the recent definition suggested by the Kidney Disease Improving Global Outcomes guidelines. METHODS: and/or urinary albumin: creatinine ratio (ACR) > 30 mg/g. RESULTS: ). CKD was higher among subjects with primary education and risk increased significantly with age; the odd ratio was more than 2-fold higher among participants aged 50-69 years. Hypertension and diabetes were associated with more than 3-fold and 4-fold higher risks of CKD [adjusted odd ratio (AOR 3.46 (95%CI 1.92, 6.24), P < 0.001] and [AOR 4.45 (2.18, 9.07), P < 0.001] respectively. Increased physical activity measured as total MET-hour/week was independently associated with a lower odds of CKD (P = 0.035). CONCLUSION: The national baseline prevalence estimate of CKD, a neglected public health problem, stresses the benefit of early detection particularly in high-risk subjects with associated cardiovascular pathologies (e.g. hypertension, diabetes), to prevent and defray costs related to eventual complications.
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Alkerwi et al. (2017) conducted a cross-sectional in Chronic kidney disease (n=1,361). Hypertension vs. Normotension was evaluated on Chronic kidney disease (CKD) (OR 3.46, 95% CI 1.92-6.24, p=<0.001). Hypertension and diabetes were independently associated with a 3.46-fold and 4.45-fold higher risk of chronic kidney disease, which had an overall prevalence of 6.3% among adults in Luxembourg.
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